structure-activityrelationship相关论文
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Novel(E)-β-Farnesene Analogues Containing 2-Nitroiminohexahydro-1,3,5-triazine:Synthesis and Biologi
To discover novel eco-friendly compounds with good activity for aphid control,(E)-β-farnesene(EβF),the main component ......
In an attempt to find the biorational pesticides, a series of novel acylthiourea derivatives of cantharidin (1) were des......
Discovery and Structure-Activity Relationship Analysis of 4-((5-nitropyrimidin-4-yl)amino)benzimidam
Protein arginine methyltransferase 1(PRMT1)is an important member of PRMT subfamily,which catalyzes the transfer of a me......
Anticancer Activities of Polyynes from the Root Bark of Oplopanax horridus and Their Acetylated Deri
Six polyynes (OH-1～6), some of which are naturally occurring acetylated, had been isolated and identified from the root b......
Design,synthesis,and structure-activity relationships of Endomorphin-1 analogues containing unnatura
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Pyruvate Kinase M2(PKM2)is a key protein responsible for cancers Warburg effect.[1],[2] Activation of PKM2 may alter abe......
Design,synthesis and biological activity of polyphenolsbenzohydrazide analogues as sphingosine kinas
The design,synthesis,and biological activity evaluation of the potency of new inhibitors of sphingosine kinases 1 and 2(......
Kv1.5 potassium channel is an efficacious and safe therapeutic target for the treatment of atrial fibrillation(AF),the m......
Breast cancer is one of the most common malignant tumor in women,both in the developed countries and developing countrie......
Design, synthesis and docking studies of novel dipeptidyl boronic acid proteasome inhibitors constru
A series of novel dipeptidyl boronic acid proteasome inhibitors constructed from αα-and αβ-amino acids were designed......
Multi-biological activities of curcumin and its analogues connecting structure-activity relationship
Curcumin,the yellow pigment present in the Indian spice turmeric derived from Curcuma longa,associated with curry powder......
Synthesis and Biological Evaluation of Novel Berberine Derivatives as Potent Inhibitors against IFN-
To explore down-regulating IDO1 expression ability of small-molecule inhibitors in tumor cells,twenty-five novel berberi......
Rhizoma Coptidis is a traditional Chinese medicine mainly consists of protoberberine alkaloids(PAs).Recent research reve......
Aim: This study aims (1) to isolate different types of compounds from Alismatis Rhizoma, a well-known traditional Chines......
Design,Synthesis and Interaction Study of Quinazoline-2(1H)-Thione Derivatives as Novel Bcl-xL Inhib
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As an important target for potential herbicides,protoporphyrinogen oxidase(PPO,EC 1.3.3.4)is the penultimate enzyme in t......
Insect kinins,a class of small biologically active peptides commonly found in arthropods and other invertebrates,play a ......
Study on the Relationship Between Sulfa Medications Retain Value of HPLC and the Numbers of Function
The relationship between sulfa medications retain value of high performance liquid chromatography (HPLC) and the numbers......
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Indirubin-3-monoxime(IM)is a potent cyclin-dependent kinase(CDK)inhibitor,Twenty novel IM derivatives were prepared to i......
1,5-Benzodiazepine Derivatives as Potential Antimicrobial Agents: Design,Synthesis,Biological Evalua
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Poly(ADP-ribose) Polymerase1(PARP1) is one of the most investigated enzymes in 18 membered PARP families and is involved......
Design,Synthesis and Interaction Study of Quinazoline-2(1H)-Thione Derivatives as Novel Bcl-xL Inhib
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Heart failure syndromes have significant impact on mortality and economic costs.Despite extensive research conducted......
Design,Synthesis and Structure-Activity Relationship Studies of 3-(Phenylethynyl)-1H-pyrazolo[3,4-d]
Triple-negative breast cancer(TNBC)is one of the most aggressive and deadly subtypes of breast cancer.[1-3] So far,t......
The leading causes of death are now diseases that involve heart and bloodvessels and as a consequence thrombosis.Fuc......
Design, Synthesis, and Pharmacological Characterization of Novel Endomorphin1 Analogues as Extremely
Recently we reported the synthesis and structure-activity study of endomorphin-1(EM-1)analogues containing novel,unn......
Investigation on the differences of four flavonoids with similar structure binding to human serum al
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Porous γ-Fe2O3 nanoparticle decorated with atomically dispersed platinum:Study on atomic site struct
Decorating semi-conducting metal oxide with noble metal has been recognized as a viable approach to improve the sensitiv......
蓝刺头是治疗骨质疏松的传统蒙药,其所含的有效成分不明确是限制其现代化、国际化发展的关键因素.传统活性物质筛选策略费时费力,......
Investigation on the differences of four flavonoids with similar structure binding to human serum al
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,Synthesis and biological evaluation of novel tricyclic matrinic derivatives as potential anti-filov
Twenty-six novel tricyclic sophoridinic and matrinic derivatives containing a common chlorinated benzene fragment were d......
